Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 11/20 | 0.57 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800674 | 0.88 | GRM1 (0.57) | GRM1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL3341175 | 0.88 | GRM1 (0.59) | GRM1GRM5MAPK14KMT2AMEN1 | |
| SCHEMBL4782600 | 0.82 | GRM1 (0.51) | GRM1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4800151 | 0.82 | GRM1 (0.51) | GRM1GRM5MAPK14KMT2AMEN1 | |
| SCHEMBL4798176 | 0.81 | GRM1 (0.55) | GRM1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4798627 | 0.77 | GRM1 (0.46) | GRM1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4799815 | 0.76 | KMT2A (0.60) | GRM1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4795503 | 0.76 | LMNA (0.40) | GRM1GRM5KMT2AMEN1RAB9A | |
| SCHEMBL4798879 | 0.75 | NPC1 (0.59) | GRM1MAPK14KMT2AMEN1RAB9A | |
| SCHEMBL4797120 | 0.75 | GRM1 (0.59) | GRM1KMT2AMEN1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |