Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801351 | 0.76 | GRM1 (0.57) | LMNAGRM1GRM5MAPTNPC1 | |
| SCHEMBL3340700 | 0.72 | KDM4E (0.56) | LMNAPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7945899 | 0.71 | APP (0.40) | LMNAPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4042164 | 0.69 | PTGS2 (0.42) | LMNAPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14380746 | 0.66 | ALOX5 (0.45) | LMNAPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL330449 | 0.65 | MAPT (0.53) | LMNAPIK3CGMAPTNPC1RAB9A | |
| SCHEMBL28127303 | 0.65 | MAPT (0.53) | LMNAPIK3CGMAPTNPC1RAB9A | |
| SCHEMBL4800674 | 0.64 | GRM1 (0.57) | LMNAGRM1L3MBTL1MAPTNPC1 | |
| SCHEMBL12943444 | 0.64 | PTGS2 (0.53) | LMNAPIK3CAL3MBTL1MAPTNPC1 | |
| SCHEMBL320589 | 0.64 | PTGS2 (0.54) | LMNAMAPTRAB9AALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |