Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801395 | 0.85 | SYK (0.76) | SYKADORA1RPS6KA3DHFRRAB9A | |
| SCHEMBL4805600 | 0.83 | SYK (0.57) | SYKDHFREGFRBCL6FGFR1 | |
| SCHEMBL4802062 | 0.83 | SYK (0.57) | SYKADORA1DHFRAURKABCL6 | |
| SCHEMBL655132 | 0.83 | SYK (0.57) | SYKADORA1RPS6KA3DHFRBCL6 | |
| SCHEMBL27612623 | 0.82 | SYK (0.53) | SYKRPS6KA3DHFRBCL6 | |
| SCHEMBL4801168 | 0.82 | SYK (0.54) | SYKADORA1RAB9ABCL6TSHR | |
| SCHEMBL4798557 | 0.81 | SYK (0.48) | SYKRPS6KA3DHFRBCL6FGFR1 | |
| SCHEMBL27631778 | 0.79 | SYK (0.50) | SYKRPS6KA3AURKAEGFRBCL6 | |
| SCHEMBL4803374 | 0.77 | RPS6KA3 (0.41) | SYKADORA1RPS6KA3BCL6KMT2A | |
| SCHEMBL4799243 | 0.77 | RPS6KA3 (0.41) | SYKADORA1RPS6KA3DHFRBCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329672-B2 | 2,4-pyrimidinediamine compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-12 | — | — | US | disclosed |