Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4799243 | 0.89 | RPS6KA3 (0.41) | RPS6KA3SYKNUDT1LCKKMT2A | |
| SCHEMBL4801741 | 0.77 | SYK (0.57) | RPS6KA3SYKKMT2AADORA1BCL6 | |
| SCHEMBL27612690 | 0.76 | RPS6KA3 (0.38) | RPS6KA3SYKNUDT1KDRJAK3 | |
| SCHEMBL4798557 | 0.75 | SYK (0.48) | RPS6KA3SYKNUDT1LCKKDR | |
| SCHEMBL4804740 | 0.71 | BCL6 (0.41) | SYKADORA1BCL6SRC | |
| SCHEMBL4802754 | 0.70 | DHFR (0.42) | SYKADORA1BCL6 | |
| SCHEMBL4801168 | 0.69 | SYK (0.54) | SYKADORA1BCL6 | |
| SCHEMBL19553895 | 0.69 | NUDT1 (0.42) | RPS6KA3SYKNUDT1BCL6NOS1 | |
| SCHEMBL655132 | 0.69 | SYK (0.57) | RPS6KA3SYKKMT2AADORA1BCL6 | |
| SCHEMBL585557 | 0.68 | TDP1 (0.46) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329672-B2 | 2,4-pyrimidinediamine compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-12 | — | — | US | disclosed |