Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | BCL6 | P41182 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801395 | 0.84 | SYK (0.76) | SYKBCL6ADORA1CYP3A4NPC1 | |
| SCHEMBL4802208 | 0.83 | SYK (0.44) | SYKBCL6MAPTKDM4ENPC1 | |
| SCHEMBL4802062 | 0.82 | SYK (0.57) | SYKBCL6ADORA1MAPTADORA2A | |
| SCHEMBL655132 | 0.82 | SYK (0.57) | SYKBCL6ADORA1ALDH1A1CYP3A4 | |
| SCHEMBL4801741 | 0.82 | SYK (0.57) | SYKBCL6ADORA1TSHRRAB9A | |
| SCHEMBL4805600 | 0.82 | SYK (0.57) | SYKBCL6 | |
| SCHEMBL4805497 | 0.80 | KMT2A (0.46) | SYKMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL4802215 | 0.79 | DHFR (0.48) | SYKMAPTKDM4EALDH1A1TDP1 | |
| SCHEMBL27612623 | 0.78 | SYK (0.53) | SYKBCL6ADORA2A | |
| SCHEMBL4804740 | 0.78 | BCL6 (0.41) | SYKBCL6ADORA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329672-B2 | 2,4-pyrimidinediamine compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-12 | — | — | US | disclosed |