Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | SMO | Q99835 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000709 | 0.90 | ALOX5AP (0.65) | ALOX5APMAPK14SMOCYP1A2CYP3A4 | |
| SCHEMBL480478 | 0.84 | ALOX5AP (0.80) | ALOX5APMAPK14SMOCYP3A4CYP2C9 | |
| SCHEMBL9924148 | 0.83 | ALOX5AP (0.71) | ALOX5APMAPK14SMOCYP3A4CYP2C9 | |
| SCHEMBL3626552 | 0.79 | ALOX5AP (0.66) | ALOX5APMAPK14SMOCYP1A2CYP3A4 | |
| SCHEMBL2999380 | 0.79 | ALOX5AP (0.66) | ALOX5APMAPK14SMOCYP3A4CYP2C9 | |
| SCHEMBL2989772 | 0.78 | ALOX5AP (0.65) | ALOX5APMAPK14SMOCYP1A2CYP3A4 | |
| SCHEMBL3000899 | 0.78 | ALOX5AP (0.65) | ALOX5APMAPK14SMOCYP1A2CYP3A4 | |
| SCHEMBL3003688 | 0.78 | ALOX5AP (0.65) | ALOX5APMAPK14SMOCYP3A4CYP2C9 | |
| SCHEMBL2996699 | 0.77 | ALOX5AP (0.58) | ALOX5APMAPK14SMOCYP1A2CYP3A4 | |
| SCHEMBL3002644 | 0.77 | ALOX5AP (0.66) | ALOX5APMAPK14SMOCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | claimed |