Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 6/20 | 0.80 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | SMO | Q99835 | 7/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924148 | 0.94 | ALOX5AP (0.71) | ALOX5APADAMTS4MAPK14SMOPDE10A | |
| SCHEMBL3000709 | 0.90 | ALOX5AP (0.65) | ALOX5APADAMTS4MAPK14SMOPDE10A | |
| SCHEMBL480273 | 0.89 | ALOX5AP (1.00) | ALOX5APADAMTS4MAPK14SMOKDM4E | |
| SCHEMBL480223 | 0.86 | ALOX5AP (0.79) | ALOX5APADAMTS4MAPK14SMOPARP10 | |
| SCHEMBL480396 | 0.85 | ALOX5AP (0.77) | ALOX5APADAMTS4MAPK14SMOPARP10 | |
| SCHEMBL480238 | 0.84 | ALOX5AP (0.65) | ALOX5APADAMTS4MAPK14SMOPDE10A | |
| SCHEMBL480228 | 0.84 | ALOX5AP (0.58) | ALOX5APADAMTS4MAPK14SMOPDE10A | |
| SCHEMBL9924147 | 0.84 | ALOX5AP (0.73) | ALOX5APADAMTS4MAPK14SMONPC1 | |
| SCHEMBL708386 | 0.83 | ALOX5AP (0.90) | ALOX5APADAMTS4MAPK14SMONPC1 | |
| SCHEMBL708385 | 0.83 | ALOX5AP (0.90) | ALOX5APADAMTS4MAPK14SMONPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440672-B2 | Diphenyl substituted alkanes | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | claimed |
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | claimed |
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168076-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | ALOX5AP 14/4885ADAMTS4 1238/4885MAPK14 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.