Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.57 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.53 |
| ▸ | PLD2 | O14939 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4798788 | 0.99 | OPRL1 (0.65) | OPRL1OPRM1PLD1PLD2ADRA1D | |
| SCHEMBL11648606 | 0.92 | OPRL1 (0.63) | OPRL1OPRM1PLD1PLD2ADRA1D | |
| SCHEMBL4808944 | 0.91 | OPRL1 (0.57) | OPRL1OPRM1PLD1PLD2CHRM1 | |
| SCHEMBL4808096 | 0.90 | OPRL1 (0.60) | OPRL1OPRM1PLD1PLD2ABCB11 | |
| Hydrochloric Acid SCHEMBL4805718 | 0.90 | OPRL1 (0.56) | OPRL1OPRM1PLD1PLD2ADRA1D | |
| SCHEMBL6628494 | 0.90 | OPRL1 (0.60) | OPRL1OPRM1PLD1PLD2ABCB11 | |
| Hydrochloric Acid SCHEMBL4805706 | 0.90 | OPRL1 (0.56) | OPRL1OPRM1PLD1PLD2ADRA1D | |
| SCHEMBL6628489 | 0.90 | OPRL1 (0.60) | OPRL1OPRM1PLD1PLD2ABCB11 | |
| Hydrochloric Acid SCHEMBL4806574 | 0.89 | OPRL1 (0.61) | OPRL1OPRM1PLD1PLD2ADRA1D | |
| SCHEMBL4807271 | 0.89 | OPRL1 (0.67) | OPRL1OPRM1PLD1PLD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | claimed |
| WO-2002074763-A9 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2002-10-24 | — | — | WO | claimed |
| US-7388020-B2 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2008-06-17 | — | — | US | disclosed |
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | disclosed |
| EP-1373248-A1 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | AstraZeneca AB (SE) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002074763-A1 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |