Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.60 |
| ▸ | CCR1 | P32246 | 3/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 5/20 | 0.48 |
| ▸ | PLD2 | O14939 | 4/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 4/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628489 | 0.94 | OPRL1 (0.60) | OPRL1CCR1ABCB11OPRM1PLD2 | |
| SCHEMBL6628494 | 0.94 | OPRL1 (0.60) | OPRL1CCR1ABCB11OPRM1PLD2 | |
| SCHEMBL4799829 | 0.91 | OPRL1 (0.57) | OPRL1CCR1OPRM1PLD2PLD1 | |
| SCHEMBL4802544 | 0.90 | OPRL1 (0.66) | OPRL1ABCB11OPRM1PLD2PLD1 | |
| SCHEMBL4806618 | 0.90 | OPRL1 (0.62) | OPRL1OPRM1PLD2PLD1 | |
| Hydrochloric Acid SCHEMBL4798788 | 0.90 | OPRL1 (0.65) | OPRL1ABCB11OPRM1PLD2PLD1 | |
| Trifluoroacetic Acid SCHEMBL4799510 | 0.89 | OPRL1 (0.55) | OPRL1CCR1ABCB11OPRM1PLD2 | |
| SCHEMBL4808944 | 0.87 | OPRL1 (0.57) | OPRL1CCR1OPRM1PLD2PLD1 | |
| Hydrochloric Acid SCHEMBL4805706 | 0.86 | OPRL1 (0.56) | OPRL1CCR1OPRM1PLD2PLD1 | |
| Hydrochloric Acid SCHEMBL4805718 | 0.86 | OPRL1 (0.56) | OPRL1CCR1OPRM1PLD2PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388020-B2 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2008-06-17 | — | — | US | claimed |
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | claimed |
| US-7388020-B2 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2008-06-17 | — | — | US | disclosed |
| US-20040116435-A1 | Benzimidazol derivatives modulate chemokine receptors | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | US | disclosed |
| EP-1373248-A1 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | AstraZeneca AB (SE) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002074763-A1 | BENZIMIDAZOL DERIVATIVES MODULATE CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |