Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255317 | 0.81 | ALDH1A1 (0.47) | PARP10ALDH1A1KMT2ABRD4BRPF1 | |
| SCHEMBL2104774 | 0.78 | PARP10 (0.56) | PARP10ALDH1A1KMT2ALMNAGAA | |
| SCHEMBL19612249 | 0.78 | CSNK2A1 (0.58) | PARP10ALDH1A1KMT2ABRD4BRPF1 | |
| SCHEMBL3721647 | 0.78 | LMNA (0.53) | PARP10ALDH1A1KMT2ABRD4BRPF1 | |
| SCHEMBL10153913 | 0.78 | KMT2A (0.53) | PARP10ALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL9647068 | 0.78 | ALDH1A1 (0.48) | PARP10ALDH1A1KMT2ABRD4BRPF1 | |
| SCHEMBL1808562 | 0.77 | CA12 (0.43) | ALDH1A1KDM4EHPGDMAPTHTT | |
| SCHEMBL14446351 | 0.76 | SMN1; SMN2 (0.44) | PARP10ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL14949898 | 0.76 | ALDH1A1 (0.43) | PARP10ALDH1A1KMT2ABRD4BRPF1 | |
| SCHEMBL2944833 | 0.76 | CYP3A4 (0.45) | PARP10ALDH1A1KMT2ABRD4BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999119-A2 | NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME | Abbott Laboratories (US) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007095602-A2 | NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME | ABBOTT LABORATORIES (US) | 2007-08-23 | — | — | WO | disclosed |