Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CBFB | Q13951 | 13/20 | 0.53 |
| ▸ | METAP2 | P50579 | 6/20 | 0.53 |
| ▸ | METAP1 | P53582 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179095 | 0.92 | NPC1 (0.80) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| Hydrochloric Acid SCHEMBL20659617 | 0.91 | NPC1 (0.78) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| SCHEMBL4813791 | 0.89 | NPC1 (0.58) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| Hydrochloric Acid SCHEMBL4813622 | 0.89 | NPC1 (0.83) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| SCHEMBL179159 | 0.82 | NPC1 (0.53) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| SCHEMBL10351275 | 0.82 | NPC1 (1.00) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| SCHEMBL179132 | 0.82 | NPC1 (0.53) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| SCHEMBL179158 | 0.81 | CBFB (0.65) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| SCHEMBL4812979 | 0.81 | METAP2 (0.67) | NPC1RAB9ARUNX1SMN1; SMN2PKM | |
| SCHEMBL4811396 | 0.81 | CBFB (0.67) | NPC1RAB9ASMN1; SMN2PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459457-B2 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2008-12-02 | — | — | US | claimed |