Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 9/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | PKM | P14618 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | UBE2N | P61088 | 1/20 | 0.61 |
| ▸ | METAP1 | P53582 | 7/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556415 | 0.92 | METAP2 (0.78) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4814803 | 0.89 | METAP2 (0.84) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4812921 | 0.89 | GAA (0.76) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL1664649 | 0.84 | SMN1; SMN2 (0.63) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4812598 | 0.84 | CBFB (0.67) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4811396 | 0.84 | CBFB (0.67) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4808230 | 0.83 | METAP2 (0.81) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4812284 | 0.81 | METAP2 (0.79) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4814508 | 0.81 | CBFB (0.69) | METAP2NPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL4805851 | 0.81 | NPC1 (0.69) | METAP2NPC1RAB9ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459457-B2 | Polycyclic pyridines as potassium ion channel modulators | ICAGEN, INC. (US) | 2008-12-02 | — | — | US | claimed |