Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.59 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.59 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.59 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL11522905 | 0.82 | CYP1A2 (0.61) | CYP1A2OR51E2GABRR1CASP1GABRA5 | |
| Bicarbonate SCHEMBL4615338 | 0.81 | CYP1A2 (0.57) | CYP1A2CASP1GABRA5GABRB2HSD17B10 | |
| Bicarbonate SCHEMBL5708571 | 0.81 | CYP1A2 (0.57) | CYP1A2CASP1GABRA5GABRB2HSD17B10 | |
| SCHEMBL28235429 | 0.81 | CASP1 (0.45) | CYP1A2CASP1LMNAPOLBADORA3 | |
| Propionic Acid SCHEMBL28783954 | 0.80 | CYP1A2 (0.58) | CYP1A2GLRA1SLC6A9OR51E2CASP1 | |
| Propionic Acid SCHEMBL9200821 | 0.80 | CYP1A2 (0.58) | CYP1A2GLRA1SLC6A9OR51E2CASP1 | |
| Adipic Acid SCHEMBL28157078 | 0.78 | LMNA (0.58) | CYP1A2GABRR1GABRA5GABRB2HSD17B10 | |
| Carbamic Acid SCHEMBL6019094 | 0.78 | CYP1A2 (0.55) | CYP1A2OR51E2CASP1GABRA5GABRB2 | |
| Bicarbonate SCHEMBL29278212 | 0.78 | CYP1A2 (0.55) | CYP1A2CASP1GABRA5GABRB2HSD17B10 | |
| Carbamic Acid SCHEMBL21315591 | 0.78 | CYP1A2 (0.55) | CYP1A2OR51E2CASP1GABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419519-B2 | Engineered non-polymeric organic particles for chemical mechanical planarization | DYNEA CHEMICALS OY (FI) | 2008-09-02 | — | — | US | disclosed |
| EP-1838795-A2 | ENGINEERED NON-POLYMERIC ORGANIC PARTICLES FOR CHEMICAL MECHANICAL PLANARIZATION | Dynea Chemicals OY (FI) | 2007-10-03 | — | — | EP | disclosed |
| US-20060261306-A1 | Engineered non-polymeric organic particles for chemical mechanical planarization | DYNEA CHEMICALS OY (FI) | 2006-11-23 | — | — | US | disclosed |
| WO-2006074248-A2 | ENGINEERED NON-POLYMERIC ORGANIC PARTICLES FOR CHEMICAL MECHANICAL PLANARIZATION | DYNEA CHEMICALS OY (FI) | 2006-07-13 | — | — | WO | disclosed |