Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 6/20 | 0.56 |
| ▸ | SULT1A1 | P50225 | 4/20 | 0.56 |
| ▸ | ILK | Q13418 | 1/20 | 0.54 |
| ▸ | RORC | P51449 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SCD | O00767 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247189 | 0.86 | MEN1 (0.58) | MAPTAPPILKRORCALDH1A1 | |
| SCHEMBL13816496 | 0.86 | APP (0.63) | MAPTSMN1; SMN2APPSULT1A1ILK | |
| SCHEMBL5423269 | 0.80 | APP (0.81) | MAPTSMN1; SMN2TP53THRBAPP | |
| SCHEMBL2244143 | 0.78 | APP (0.72) | MAPTSMN1; SMN2TP53THRBAPP | |
| SCHEMBL23170966 | 0.78 | MAPT (0.64) | MAPTSMN1; SMN2TP53APPRORC | |
| SCHEMBL19029213 | 0.77 | HDAC6 (0.58) | MAPTSMN1; SMN2TP53RORCALDH1A1 | |
| SCHEMBL13254486 | 0.77 | MAPT (0.70) | MAPTSMN1; SMN2TP53THRBAPP | |
| SCHEMBL11887840 | 0.75 | KDM4E (0.78) | MAPTSMN1; SMN2TP53THRBAPP | |
| SCHEMBL4801603 | 0.75 | MAPT (0.64) | MAPTSMN1; SMN2TP53THRBAPP | |
| SCHEMBL10701932 | 0.75 | MAPT (0.66) | MAPTSMN1; SMN2TP53THRBAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384966-B2 | 2-arylbenzothiazole derivatives | PHARMINXO LIMITED (GB) | 2008-06-10 | — | — | US | disclosed |
| US-20060063816-A1 | 2-Arylbenzothiazole derivatives | STEVENS MALCOLM F G | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063816-A1 | 2-Arylbenzothiazole derivatives | CX3CR1, HCN2, CYBB | MAPT 4559/4885SMN1; SMN2 3362/4885TP53 3085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.