Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4807912 | 1.00 | PPARG (0.44) | PPARGPPARAGSK3BALDH1A1DRD4 | |
| SCHEMBL15239274 | 0.85 | CA1 (0.48) | GSK3BALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL15239276 | 0.85 | CA1 (0.48) | GSK3BALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8017837 | 0.84 | TSHR (0.48) | PPARAGSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL8017835 | 0.84 | TSHR (0.48) | PPARAGSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL4806906 | 0.83 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL4806901 | 0.83 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL6811236 | 0.79 | TRPA1 (0.49) | GSK3BDRD4RAB9ADRD2MEN1 | |
| SCHEMBL4467279 | 0.77 | GSK3B (0.71) | PPARGPPARAGSK3BALDH1A1DRD4 | |
| SCHEMBL4467283 | 0.77 | GSK3B (0.71) | PPARGPPARAGSK3BALDH1A1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390925-B2 | Oxime-containing acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-24 | — | — | US | disclosed |
| US-7390925-B2 | Oxime-containing acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-24 | — | — | US | disclosed |
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-10-04 | — | — | US | disclosed |
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BACE1, APP, BACE2 | PPARG 2948/4885PPARA 3555/4885GSK3B 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.