Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740568 | 0.84 | PIN1 (0.54) | PIN1NR4A2MEN1NPC1USP2 | |
| SCHEMBL18051320 | 0.78 | SCN2A (0.45) | PIN1MEN1NPC1POLBMAPT | |
| SCHEMBL2293472 | 0.72 | SCN2A (0.55) | PIN1MEN1NPC1USP2POLB | |
| SCHEMBL20308844 | 0.71 | NPSR1 (0.41) | PIN1MEN1NPC1USP2POLB | |
| SCHEMBL4810690 | 0.69 | NR4A2 (0.52) | NR4A2MEN1NPC1POLBMAPT | |
| SCHEMBL14196050 | 0.69 | PIN1 (0.59) | PIN1MEN1NPC1POLBMAPT | |
| SCHEMBL4808367 | 0.69 | PIN1 (0.59) | PIN1MEN1NPC1POLBMAPT | |
| SCHEMBL9590158 | 0.69 | HDAC2 (0.59) | NR4A2NPC1L3MBTL1IP6K1IP6K2 | |
| N,N-Dimethylcinnamamide SCHEMBL783551 | 0.68 | NPC1 (0.65) | NPC1MAPTRAB9AKMT2AL3MBTL1 | |
| N,N-Dimethylcinnamamide SCHEMBL3743395 | 0.68 | NPC1 (0.65) | NPC1MAPTRAB9AKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |
| US-20040097531-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097531-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | LCK, AURKC, CDK5 | PIN1 1062/4885NR4A2 3964/4885MEN1 3978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.