Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14196050 | 1.00 | PIN1 (0.59) | PIN1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6106389 | 0.76 | HTT (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6106392 | 0.76 | HTT (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL10242707 | 0.76 | PIN1 (0.74) | PIN1SMN1; SMN2MAPTRECQLNPY5R | |
| SCHEMBL3057838 | 0.75 | PIN1 (1.00) | PIN1RECQLNPY5RSCN2A | |
| SCHEMBL10858317 | 0.74 | PIN1 (0.62) | PIN1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10858310 | 0.74 | PIN1 (0.62) | PIN1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5783094 | 0.72 | HTT (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL25478641 | 0.72 | PIN1 (0.74) | PIN1RAB9ARECQLNPY5RSCN2A | |
| SCHEMBL23833724 | 0.72 | PIN1 (0.74) | PIN1RECQLNPY5RSCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |
| US-20040097531-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097531-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | LCK, AURKC, CDK5 | PIN1 1062/4885ALDH1A1 4564/4885SMN1; SMN2 3100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.