Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | CA7 | P43166 | 1/20 | 0.68 |
| ▸ | CA9 | Q16790 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 3/20 | 0.61 |
| ▸ | BCHE | P06276 | 2/20 | 0.61 |
| ▸ | BACE1 | P56817 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818022 | 0.87 | CA1 (0.76) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL3838144 | 0.85 | CA1 (0.55) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL29078385 | 0.85 | L3MBTL1 (0.67) | CA1CA2CA7CA9L3MBTL1 | |
| SCHEMBL5626457 | 0.83 | ALDH1A1 (0.74) | L3MBTL1ALDH1A1KDM4EACHEBCHE | |
| SCHEMBL4818357 | 0.83 | CA1 (0.74) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL3844592 | 0.82 | HTT (0.79) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL9610816 | 0.81 | KDM4E (0.65) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL8034304 | 0.81 | KDM4E (0.65) | L3MBTL1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL4474974 | 0.79 | ALDH1A1 (0.70) | L3MBTL1ALDH1A1KDM4ESIGMAR1SMN1; SMN2 | |
| SCHEMBL29078365 | 0.79 | CYP2C19 (0.61) | L3MBTL1ALDH1A1KDM4ESIGMAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332495-B2 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | NHWA PHARMA. CORPORATION (CN) | 2008-02-19 | — | — | US | claimed |
| US-20060148811-A1 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2006-07-06 | — | — | US | claimed |
| US-7332495-B2 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | NHWA PHARMA. CORPORATION (CN) | 2008-02-19 | — | — | US | disclosed |
| US-20060148811-A1 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148811-A1 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent | AAK1, KCNJ1, KHK | CA1 3427/4885CA2 1495/4885CA7 1576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.