Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812480 | 0.85 | CHEK1 (0.47) | KMT2AMEN1CHEK1ALDH1A1ROCK2 | |
| SCHEMBL4814690 | 0.71 | CHEK1 (0.71) | KMT2AMEN1CHEK1ALDH1A1ROCK2 | |
| SCHEMBL4820064 | 0.67 | LMNA (0.43) | KMT2AMEN1ALDH1A1ROCK2ROCK1 | |
| SCHEMBL4816427 | 0.66 | HRH1 (0.32) | KMT2AMEN1NPC1 | |
| SCHEMBL4808567 | 0.65 | KDR (0.36) | ALDH1A1HPGDKDM4E | |
| SCHEMBL19473341 | 0.64 | NPC1 (0.68) | KMT2AMEN1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL1788936 | 0.64 | KDM4E (0.57) | KMT2AMEN1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9179703 | 0.64 | KMT2A (0.71) | KMT2AMEN1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL13947091 | 0.64 | KDM4E (0.70) | KMT2AMEN1ROCK2ROCK1HPGD | |
| SCHEMBL13175833 | 0.63 | KMT2A (0.66) | KMT2AMEN1ROCK2ROCK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | KMT2A 3073/4885MEN1 1900/4885CHEK1 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.