Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.50 |
| ▸ | DRD4 | P21917 | 7/20 | 0.50 |
| ▸ | HRH2 | P25021 | 4/20 | 0.49 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14002041 | 1.00 | MCHR1 (0.51) | MCHR1DRD2DRD4HRH2HRH1 | |
| SCHEMBL6106470 | 1.00 | MCHR1 (0.51) | MCHR1DRD2DRD4HRH2HRH1 | |
| SCHEMBL7568071 | 0.89 | HRH2 (0.61) | MCHR1DRD2DRD4HRH2HRH1 | |
| SCHEMBL28249803 | 0.89 | HRH2 (0.61) | MCHR1DRD2DRD4HRH2HRH1 | |
| SCHEMBL7568066 | 0.89 | HRH2 (0.61) | MCHR1DRD2DRD4HRH2HRH1 | |
| SCHEMBL9384147 | 0.89 | HRH2 (0.61) | MCHR1DRD2DRD4HRH2HRH1 | |
| SCHEMBL2241423 | 0.86 | KMT2A (0.63) | MCHR1DRD2DRD4BACE1KMT2A | |
| SCHEMBL2241424 | 0.86 | KMT2A (0.63) | MCHR1DRD2DRD4BACE1KMT2A | |
| SCHEMBL178929 | 0.86 | KMT2A (0.63) | MCHR1DRD2DRD4BACE1KMT2A | |
| SCHEMBL7415020 | 0.85 | UTS2R (0.62) | DRD2DRD4HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446115-B2 | To treat pain, drug addiction, or tinnitus; selectively inhibit sodium or calcium ion channels and agonize or antagonize mu -opioid receptors; N-Benzyl-N-(2-dimethylamino-ethyl)-2-(S)-[3-(4-fluorophenyl)-ureido]-3-methyl-butyramide | SEPRACOR, INC. (US) | 2008-11-04 | — | — | US | disclosed |
| US-20070093522-A1 | Peptidomimetic ligands for cellular receptors and ion channels | PERSONS PAUL E | 2007-04-26 | — | — | US | disclosed |
| US-7115664-B2 | Peptidomimetic ligands for cellular receptors and ion channels | SEPRACOR INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20050080271-A1 | Peptidomimetic ligands for cellular receptors and ion channels | SEPRACOR INC. | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093522-A1 | Peptidomimetic ligands for cellular receptors and ion channels | OPRL1, TRPV1, ORAI1 | MCHR1 229/4885DRD2 455/4885DRD4 775/4885 |
| US-20050080271-A1 | Peptidomimetic ligands for cellular receptors and ion channels | TRPV1, OPRL1, TRPV2 | MCHR1 326/4885DRD2 717/4885DRD4 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.