Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.61 |
| ▸ | HRH1 | P35367 | 2/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 8/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568066 | 1.00 | HRH2 (0.61) | HRH2HRH1MCHR1DRD4DRD2 | |
| SCHEMBL7568071 | 1.00 | HRH2 (0.61) | HRH2HRH1MCHR1DRD4DRD2 | |
| SCHEMBL28249803 | 1.00 | HRH2 (0.61) | HRH2HRH1MCHR1DRD4DRD2 | |
| SCHEMBL6106470 | 0.89 | MCHR1 (0.51) | HRH2HRH1MCHR1DRD4DRD2 | |
| SCHEMBL4809583 | 0.89 | MCHR1 (0.51) | HRH2HRH1MCHR1DRD4DRD2 | |
| SCHEMBL14002041 | 0.89 | MCHR1 (0.51) | HRH2HRH1MCHR1DRD4DRD2 | |
| SCHEMBL7402928 | 0.88 | UTS2R (0.62) | HRH2HRH1DRD4DRD2 | |
| SCHEMBL7400619 | 0.88 | UTS2R (0.62) | HRH2HRH1DRD4DRD2 | |
| SCHEMBL7415020 | 0.88 | UTS2R (0.62) | HRH2HRH1DRD4DRD2 | |
| SCHEMBL2241423 | 0.87 | KMT2A (0.63) | MCHR1DRD4DRD2BACE1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602823-A | As deubiquitinating enzymes（DUB）The spiral shell of inhibitor-condensation pyrrolidin derivatives | 特殊治疗有限公司 | 2018-09-28 | — | — | CN | disclosed |
| EP-0304087-B1 | Quinolone and naphthyridine antibacterial agents containing an alpha-amino acid in the side chain of the 7-substituent | WARNER LAMBERT CO (US) | 1994-03-30 | — | — | EP | disclosed |
| US-4851418-A | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent | WARNER-LAMBERT COMPANY (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0304087-A2 | Quinolone and naphthyridine antibacterial agents containing an alpha-amino acid in the side chain of the 7-substituent | WARNER-LAMBERT COMPANY (US) | 1989-02-22 | — | — | EP | disclosed |