Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4809724 | 1.00 | ALDH1A1 (0.51) | ALDH1A1GAAKMT2AMAPTHPGD | |
| SCHEMBL5148094 | 0.85 | GAA (0.54) | ALDH1A1GAAKMT2AMAPTMEN1 | |
| SCHEMBL8063117 | 0.83 | MAPT (0.51) | ALDH1A1MAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL4806906 | 0.81 | ALDH1A1 (0.52) | ALDH1A1GAAKMT2APKMMEN1 | |
| SCHEMBL4806901 | 0.81 | ALDH1A1 (0.52) | ALDH1A1GAAKMT2APKMMEN1 | |
| SCHEMBL9180317 | 0.80 | MAPT (0.47) | ALDH1A1GAAKMT2AMAPTHPGD | |
| SCHEMBL9180324 | 0.80 | MAPT (0.47) | ALDH1A1GAAKMT2AMAPTHPGD | |
| SCHEMBL314216 | 0.80 | HDAC3 (0.60) | ALDH1A1KMT2AMAPTHPGDHDAC3 | |
| SCHEMBL25917253 | 0.79 | CTSK (0.53) | ALDH1A1GAAKMT2AMAPTHPGD | |
| SCHEMBL9516341 | 0.78 | ALDH1A1 (0.43) | ALDH1A1GAAKMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390925-B2 | Oxime-containing acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-24 | — | — | US | disclosed |
| US-7390925-B2 | Oxime-containing acyl guanidines as beta-secretase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-24 | — | — | US | disclosed |
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-10-04 | — | — | US | disclosed |
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232581-A1 | Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors | BACE1, APP, BACE2 | ALDH1A1 1599/4885GAA 70/4885KMT2A 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.