Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27535758 | 0.84 | ALDH1A1 (0.53) | LMNAHTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL27846469 | 0.82 | ALDH1A1 (0.51) | LMNAHTTALDH1A1 | |
| SCHEMBL434576 | 0.81 | ALDH1A1 (0.56) | LMNAMEN1KMT2ARAB9AMAPT | |
| SCHEMBL18097664 | 0.77 | SRD5A2 (0.56) | RAB9AHTTALDH1A1CES2CES1 | |
| SCHEMBL132367 | 0.77 | LMNA (0.73) | LMNAMEN1KMT2ARAB9AMAPT | |
| SCHEMBL3842531 | 0.77 | LMNA (0.73) | LMNAMEN1KMT2ARAB9AMAPT | |
| SCHEMBL9126141 | 0.77 | LMNA (0.73) | LMNAMEN1KMT2ARAB9AMAPT | |
| SCHEMBL29984922 | 0.75 | LMNA (0.70) | LMNAMEN1KMT2ARAB9AMAPT | |
| Ethylene SCHEMBL10490014 | 0.73 | LMNA (0.67) | LMNAMEN1KMT2ARAB9AMAPT | |
| SCHEMBL15087996 | 0.72 | SMN1; SMN2 (0.62) | LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345050-B2 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2008-03-18 | — | — | US | disclosed |
| US-20040077642-A1 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2004-04-22 | — | — | US | disclosed |
| EP-1373266-A2 | (DIAZOLO-PYRIDINYL)-PYRIMIDINES FOR USE IN TREATMENT OF CNS DISORDERS AND DIABETES | AstraZeneca AB (SE) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002065979-A2 | (DIAZOLO-PYRIDINYL)-PYRIMIDINES FOR USE IN TREATMENT OF CNS DISORDERS AND DIABETES | ASTRAZENECA AB (SE) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077642-A1 | Pyrimidine compounds | TYMP, DPYD, TYMS | LMNA 1945/4885MEN1 2105/4885KMT2A 2688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.