Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | DUT | P33316 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9116620 | 0.87 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2DUTHPGDRECQL | |
| SCHEMBL3902712 | 0.85 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2DUTHPGDRECQL | |
| SCHEMBL23772645 | 0.85 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2DUTHPGDRECQL | |
| SCHEMBL23772642 | 0.85 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2DUTHPGDRECQL | |
| SCHEMBL11522117 | 0.82 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HPGDCAMK2ARECQL | |
| SCHEMBL19171550 | 0.82 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2DUTHPGDNPC1 | |
| SCHEMBL9462903 | 0.81 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2DUTHPGDHRH3 | |
| SCHEMBL19500461 | 0.79 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2DUTHPGDRECQL | |
| SCHEMBL23176207 | 0.79 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2DUTHPGDRECQL | |
| SCHEMBL9462966 | 0.79 | ALDH1A1 (0.61) | ALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361753-B2 | Phosphotriester-modified oligonucleotide primers for nucleic acid amplification | TRILINK BIOTECHNOLOGIES, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| EP-2032714-B1 | CHEMICALLY MODIFIED OLIGONUCLEOTIDE PRIMERS FOR NUCLEIC ACID AMPLIFICATION | TRILINK BIOTECHNOLOGIES (US) | 2011-03-16 | — | — | EP | disclosed |
| US-7355037-B2 | Thermolabile hydroxyl protecting groups and methods of use | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-04-08 | — | — | US | disclosed |
| US-20050020827-A1 | Thermolabile hydroxyl protecting groups and methods of use | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2005-01-27 | — | — | US | disclosed |
| US-6762298-B2 | DEPROTECTING AN OLIGONUCLEOTIDE BY HEATING IN A FLUID, WHERE THE PHOSPHORUS ATOM IS O-PROTECTED WITH A THERMOLABILE GROUP SUCH AS (PYRROLIDIN-1-ONE-1-YL)ALKYL; SYNTHESIS OF OLIGONUCLEOTIDES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2004-07-13 | — | — | US | disclosed |
| WO-2003048179-A2 | THERMOLABILE HYDROXYL PROTECTING GROUPS AND METHODS OF USE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-06-12 | — | — | WO | disclosed |
| US-20010044529-A1 | Thermolabile phosphorus protecting groups, associated intermediates and methods of use | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2001-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020827-A1 | Thermolabile hydroxyl protecting groups and methods of use | ADH1A, NR2C2, NR1H2 | ALDH1A1 200/4885SMN1; SMN2 4139/4885DUT 1597/4885 |
| US-20010044529-A1 | Thermolabile phosphorus protecting groups, associated intermediates and methods of use | POLR2H, POLL, POLR1A | ALDH1A1 1410/4885SMN1; SMN2 1214/4885DUT 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.