Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025302 | 0.84 | HTR6 (0.73) | HTR6MTNR1AAKR1C3MTNR1BAKR1C2 | |
| SCHEMBL3018944 | 0.82 | HTR6 (0.53) | HTR6MTNR1AAKR1C3MTNR1BAKR1C2 | |
| SCHEMBL3032670 | 0.80 | HTR6 (0.52) | HTR6MTNR1AAKR1C3MTNR1BAKR1C2 | |
| SCHEMBL15242222 | 0.80 | MTNR1A (0.70) | HTR6MTNR1AMTNR1BNQO2PPARG | |
| SCHEMBL5654827 | 0.78 | HTR6 (0.54) | HTR6MTNR1AAKR1C3MTNR1BAKR1C2 | |
| SCHEMBL3036311 | 0.78 | MTNR1A (0.74) | HTR6MTNR1AMTNR1BPPARGPPARD | |
| SCHEMBL3030043 | 0.76 | PPARG (0.75) | HTR6PPARGPPARDPPARA | |
| SCHEMBL3029516 | 0.75 | HTR6 (0.76) | HTR6MTNR1AAKR1C3AKR1C2PPARG | |
| SCHEMBL3034823 | 0.74 | PPARG (0.55) | HTR6MTNR1AAKR1C3MTNR1BAKR1C2 | |
| SCHEMBL24878466 | 0.73 | HTR6 (0.53) | HTR6MTNR1AAKR1C3MTNR1BAKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348338-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2008-03-25 | — | — | US | disclosed |
| US-20050288354-A1 | PPAR active compounds | PLEXXIKON, INC. | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288354-A1 | PPAR active compounds | PPARG, PPARD, PPARA | HTR6 1004/4885MTNR1A 488/4885AKR1C3 3189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.