Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 15/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 15/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30736074 | 0.82 | CYP1A2 (0.50) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL480388 | 0.82 | CYP1A2 (0.50) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL10806255 | 0.81 | GRM2 (0.38) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL13452821 | 0.81 | PPARG (0.48) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL6932259 | 0.81 | PPARG (0.48) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL6401236 | 0.80 | PPARG (0.46) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL9174003 | 0.80 | CYSLTR2 (0.49) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL481392 | 0.79 | PPARG (0.47) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL481043 | 0.79 | PPARG (0.45) | GRM2CYSLTR2CYSLTR1LMNAPPARG | |
| SCHEMBL9177662 | 0.78 | CYSLTR2 (0.50) | GRM2CYSLTR2CYSLTR1LMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441762-A1 | Potentiators of Glutamate Receptors | Eli Lilly and Company (US) | 2012-04-18 | — | — | EP | disclosed |
| EP-1817301-B1 | POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | disclosed |
| US-8026282-B2 | Phenoxyalkylcarboxylic acid derivatives in the treatment of irritable bowel syndrome | MEDICINOVA, INC. (US) | 2011-09-27 | — | — | US | disclosed |
| US-8026282-B2 | Phenoxyalkylcarboxylic acid derivatives in the treatment of irritable bowel syndrome | MEDICINOVA, INC. (US) | 2011-09-27 | — | — | US | disclosed |
| US-7858646-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100285074-A1 | PHENOXYALKYLCARBOXYLIC ACID DERIVATIVES IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | MEDICINOVA, INC. | 2010-11-11 | — | — | US | disclosed |
| US-20100285074-A1 | PHENOXYALKYLCARBOXYLIC ACID DERIVATIVES IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | MEDICINOVA, INC. | 2010-11-11 | — | — | US | disclosed |
| US-7816523-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2010-10-19 | — | — | US | disclosed |
| US-7803938-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2010-09-28 | — | — | US | disclosed |
| US-7786169-B2 | Phenoxyalkycarboxylic acid derivatives in the treatment of ulcerative colitis | MEDICINOVA, INC. (US) | 2010-08-31 | — | — | US | disclosed |
| EP-0056172-B1 | PHENOXY- AND THIOPHENOXY COMPOUNDS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | FISONS plc (GB) | 1985-04-03 | — | — | EP | disclosed |
| EP-0068739-B1 | SULPHUR-CONTAINING 5-HYDROXY-ALKANOIC ACID DERIVATIVES, THEIR USE AS PHARMACEUTICAL PREPARATIONS AND PROCESS FOR THEIR PRODUCTION | Lilly Industries Limited (GB) | 1984-11-14 | — | — | EP | disclosed |
| EP-0123543-A1 | Leukotriene antagonists, their production and use and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-10-31 | — | — | EP | disclosed |
| US-4474788-A | Anti-SRSA quinoline carboxylic acid derivatives | FISONS PLC (GB) | 1984-10-02 | — | — | US | disclosed |
| US-4424231-A | Compounds | FISONS LIMITED (GB) | 1984-01-03 | — | — | US | disclosed |
| EP-0079637-A1 | Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them | FISONS plc (GB) | 1983-05-25 | — | — | EP | disclosed |
| EP-0068739-A1 | Sulphur-containing 5-hydroxy-alkanoic acid derivatives, their use as pharmaceutical preparations and process for their production | Lilly Industries Limited (GB) | 1983-01-05 | — | — | EP | disclosed |
| EP-0061800-A1 | Anti SRS-A carboxylic acid derivatives, processes for their production and pharmaceutical formulations containing them | FISONS plc (GB) | 1982-10-06 | — | — | EP | disclosed |
| EP-0056172-A2 | Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them | FISONS plc (GB) | 1982-07-21 | — | — | EP | disclosed |
| US-4228173-A | Thiopyrano-benzopyrans, compositions and method of use thereof | FISONS LIMITED (GB) | 1980-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100285074-A1 | PHENOXYALKYLCARBOXYLIC ACID DERIVATIVES IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME | SI, SLC10A2, HCAR2 | GRM2 233/4885CYSLTR2 78/4885CYSLTR1 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.