Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417922 | 0.90 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL9121707 | 0.89 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL1024088 | 0.88 | HTT (0.62) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL6756073 | 0.87 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL10382709 | 0.87 | TYR (0.47) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL4344454 | 0.85 | HTT (0.48) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL10807511 | 0.85 | HTT (0.48) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL8654136 | 0.84 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL2003391 | 0.82 | POLB (0.53) | HSP90AA1HSP90AB1PKMHTTALDH1A1 | |
| SCHEMBL9616832 | 0.82 | PKM (0.68) | HSP90AA1HSP90AB1PKMHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817301-B1 | POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | claimed |
| US-7598423-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2009-10-06 | — | — | US | claimed |
| US-20080139505-A1 | Potentiators Of Glutamate Receptors | ARRAY BIOPHARMA, INC. | 2008-06-12 | — | — | US | claimed |
| EP-1817301-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | claimed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | claimed |
| EP-0242230-B1 | Pyrido [1,2-a] pyrimidine derivatives | TOKYO TANABE COMPANY LIMITED (JP) | 1990-10-03 | — | — | EP | claimed |
| EP-0217673-B1 | Pyrido [1,2-a]pyrimidine derivatives | TOKYO TANABE COMPANY LIMITED (JP) | 1989-12-27 | — | — | EP | claimed |
| EP-0242230-A2 | Pyrido [1,2-a] pyrimidine derivatives | TOKYO TANABE COMPANY LIMITED (JP) | 1987-10-21 | — | — | EP | claimed |
| EP-0217673-A1 | Pyrido [1,2-a]pyrimidine derivatives | TOKYO TANABE COMPANY LIMITED (JP) | 1987-04-08 | — | — | EP | claimed |
| JP-62242682-A | — | — | None | — | — | JP | disclosed |
| JP-7291889-A | — | — | None | — | — | JP | disclosed |
| JP-1125380-A | — | — | None | — | — | JP | disclosed |
| JP-63183581-A | — | — | None | — | — | JP | disclosed |
| JP-1193223-A | — | — | None | — | — | JP | disclosed |
| EP-0017332-A1 | Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them | FISONS plc (GB) | 1980-10-15 | — | — | EP | disclosed |
| US-4211791-A | Indanediones | BEECHAM GROUP LIMITED (GB) | 1980-07-08 | — | — | US | disclosed |
| US-4207335-A | ANTIALLERGENS | BEECHAM GROUP LIMITED (GB) | 1980-06-10 | — | — | US | disclosed |
| US-4200577-A | ANTIALLERGENS, ANTIHISTAMINES | BEECHAM GROUP LIMITED (GB) | 1980-04-29 | — | — | US | disclosed |
| US-4136192-A | ANTIALLERGENS | BEECHAM GROUP LIMITED (GB) | 1979-01-23 | — | — | US | disclosed |
| US-4133889-A | ANAPHYLAXIS ANTAGONISTS | FISONS, LTD. (GB) | 1979-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139505-A1 | Potentiators Of Glutamate Receptors | GRM1, GRIN1, GRM2 | HSP90AA1 3869/4885HSP90AB1 3796/4885PKM 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.