Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | AGXT | P21549 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 10/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033057 | 0.83 | IDO1 (0.50) | IDO1AGXTMAOBTAAR1MAOA | |
| SCHEMBL145704 | 0.79 | MAOB (0.43) | IDO1MAOBMAOA | |
| SCHEMBL481295 | 0.78 | IDO1 (0.47) | IDO1MAOBTAAR1PYCR1 | |
| SCHEMBL1315107 | 0.77 | TSHR (0.46) | IDO1AGXTTAAR1SIGMAR1MAOA | |
| SCHEMBL9207416 | 0.77 | IDO1 (0.44) | IDO1AGXTMAOBTAAR1SIGMAR1 | |
| SCHEMBL30350635 | 0.77 | IDO1 (0.58) | IDO1AGXTMAOBTAAR1MAOA | |
| SCHEMBL13412791 | 0.77 | IDO1 (0.58) | IDO1AGXTMAOBTAAR1MAOA | |
| SCHEMBL9197307 | 0.76 | IDO1 (0.50) | IDO1AGXTMAOBTAAR1MAOA | |
| SCHEMBL3507204 | 0.76 | TACR1 (0.38) | HCAR2 | |
| SCHEMBL25219446 | 0.76 | MAOA (0.48) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441762-A1 | Potentiators of Glutamate Receptors | Eli Lilly and Company (US) | 2012-04-18 | — | — | EP | disclosed |
| EP-1817301-B1 | POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2012-02-01 | — | — | EP | disclosed |
| US-7816523-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2010-10-19 | — | — | US | disclosed |
| US-7803938-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2010-09-28 | — | — | US | disclosed |
| US-20090318481-A1 | Potentiators Of Glutamate Receptors | AICHER THOMAS DANIEL | 2009-12-24 | — | — | US | disclosed |
| US-20090318483-A1 | Potentiators Of Glutamate Receptors | AICHER THOMAS DANIEL | 2009-12-24 | — | — | US | disclosed |
| US-7625937-B2 | 1H-benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7598423-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY (US) | 2009-10-06 | — | — | US | disclosed |
| US-20080139505-A1 | Potentiators Of Glutamate Receptors | ARRAY BIOPHARMA, INC. | 2008-06-12 | — | — | US | disclosed |
| US-20080076795-A1 | 1H-benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. | 2008-03-27 | — | — | US | disclosed |
| US-7282591-B2 | 1h-benzo{f}indazol-5-yl derivatives as selective glucocorticoid receptor modulators | MERCK & CO., INC. (US) | 2007-10-16 | — | — | US | disclosed |
| EP-1817301-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139505-A1 | Potentiators Of Glutamate Receptors | GRM1, GRIN1, GRM2 | IDO1 2210/4885AGXT 949/4885MAOB 1372/4885 |
| US-20090318481-A1 | Potentiators Of Glutamate Receptors | GRIK1, GRIK2, GRIK4 | IDO1 3036/4885AGXT 1731/4885MAOB 1955/4885 |
| US-20080076795-A1 | 1H-benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators | NR3C1, NR3C2, GRK5 | IDO1 1210/4885AGXT 4017/4885MAOB 4368/4885 |
| US-20090318483-A1 | Potentiators Of Glutamate Receptors | GRIK1, GRIK2, GRIK4 | IDO1 3036/4885AGXT 1731/4885MAOB 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.