Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.45 |
| ▸ | FEN1 | P39748 | 5/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790510 | 0.77 | PTGS2 (0.51) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL19286143 | 0.70 | ALOX5AP (0.77) | ALOX5APFEN1 | |
| SCHEMBL10264753 | 0.69 | USP7 (0.50) | HSD11B1RAB9ALMNANPSR1KMT2A | |
| SCHEMBL28026386 | 0.69 | RAB9A (0.50) | PTGS2PTGS1ALOX5APFEN1HSD11B1 | |
| SCHEMBL16113473 | 0.68 | ALOX5AP (0.48) | PTGS2PTGS1ALOX5APFEN1HSD11B1 | |
| SCHEMBL17973841 | 0.67 | MAPT (0.45) | PTGS2ALDH1A1KMT2A | |
| SCHEMBL28066 | 0.67 | PTGS2 (0.48) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL8770064 | 0.67 | ALOX5AP (0.47) | PTGS2PTGS1ALOX5APFEN1HSD11B1 | |
| SCHEMBL1030260 | 0.66 | ALOX5AP (0.59) | ALOX5APFEN1 | |
| SCHEMBL6901981 | 0.66 | PTGS2 (0.68) | PTGS2PTGS1ALOX5APFEN1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135829-A2 | NANOPARTICLES COMPRISING COX-2 INHIBITORS AND A NON-IONIZABLE POLYMER | PFIZER PRODUCTS INC. (GB) | 2008-11-13 | — | — | WO | disclosed |