SCHEMBL481450

SCHEMBL481450

C=C(C(=O)O)c1ccc(Cl)cc1Cl

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.64
CASP1 P29466 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
ERCC5 P28715 2/20 0.56
FEN1 P39748 2/20 0.56
ALDH1A1 P00352 4/20 0.53
MAPK1 P28482 1/20 0.53
HIF1A Q16665 1/20 0.53
MAPT P10636 3/20 0.52
KDM4E B2RXH2 1/20 0.52
SRD5A2 P31213 1/20 0.51
TP53 P04637 1/20 0.48
POLB P06746 3/20 0.47
CYP3A4 P08684 1/20 0.47
HPGD P15428 1/20 0.47
FLT1 P17948 2/20 0.45
FLT4 P35916 2/20 0.45
KDR P35968 2/20 0.45
THRB P10828 1/20 0.45
RECQL P46063 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31162470 0.82 SMN1; SMN2 (0.57) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL9812567 0.82 HSD17B10 (0.45) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL9668242 0.82 SMN1; SMN2 (0.57) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL24719501 0.81 FLT1 (0.44) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL29259275 0.81 SMN1; SMN2 (0.46) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL28601067 0.81 FLT1 (0.46) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL2358618 0.80 SMN1; SMN2 (0.55) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL4672044 0.79 SMN1; SMN2 (0.53) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL1697496 0.79 TSHR (0.69) TSHRCASP1SMN1; SMN2ERCC5FEN1
SCHEMBL111279 0.79 TSHR (1.00) TSHRCASP1SMN1; SMN2ERCC5FEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7723425-B2 Pigment compositions with modified ATRP copolymer dispersants CIBA SPECIALTY CHEMICALS CORPORATION (US) 2010-05-25 US claimed
WO-2023094549-A1 FLEXIBLE PRESSURE-SENSITIVE ADHESIVES HAVING IMPROVED PROPERTIES WESTFÄLISCHE HOCHSCHULE GELSENKIRCHEN BOCHOLT RECKLINGHAUSEN (DE) 2023-06-01 WO disclosed
EP-1465935-B1 PIGMENT COMPOSITIONS WITH MODIFIED ATRP COPOLYMER DISPERSANTS BASF SE (DE) 2016-09-07 EP disclosed
EP-2411437-B9 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK CHEMIE GMBH (DE) 2013-07-31 EP disclosed
EP-2411437-B1 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK CHEMIE GMBH (DE) 2013-05-08 EP disclosed
EP-1611197-B1 LIGHT STABILISING POLYMER DISPERSANTS IN PIGMENT DISPERSIONS BASF SE (DE) 2012-03-21 EP disclosed
US-20120029104-A1 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK-CHEMIE GMBH (DE) 2012-02-02 US disclosed
EP-2411437-A2 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK-Chemie GmbH (DE) 2012-02-01 EP disclosed
WO-2010108672-A2 COMPOSITION COMPRISING STABLE POLYOL MIXTURES BYK-CHEMIE GMBH (DE) 2010-09-30 WO disclosed
US-20060229407-A1 Light stabilising polymer dispersants in pigment dispersions CIBA SPECIALTY CHEMICALS CORP. 2006-10-12 US disclosed
US-20060160940-A1 Process for intercalating natural or szynthetic clays with block or comb copolymers CIBA SPECIALTY CHEMICALS CORP. 2006-07-20 US disclosed
US-6849679-B2 Pigment compositions with modified block copolymer dispersants CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-02-01 US disclosed
EP-0765351-B1 AMIDATION OF ESTER FUNCTIONALIZED HYDROCARBON POLYMERS EXXON CHEMICAL PATENTS INC (US) 1999-01-13 EP disclosed
US-5627259-A REACTION OF OLEFIN POLYMERS WITH CARBON MONOXIDE AND ALCOHOL THEN REACTION OF ESTER WITH POLYAMINE COMPOUND RELEASING ALCOHOL COMPOUND EXXON CHEMICAL PATENTS INC. (US) 1997-05-06 US disclosed
EP-0765351-A1 AMIDATION OF ESTER FUNCTIONALIZED HYDROCARBON POLYMERS EXXON CHEMICAL PATENTS INC. (US) 1997-04-02 EP disclosed
WO-1995035330-A1 AMIDATION OF ESTER FUNCTIONALIZED HYDROCARBON POLYMERS EXXON CHEMICAL PATENTS INC. (US) 1995-12-28 WO disclosed
EP-0099165-A1 Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-01-25 EP disclosed