Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 5/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.33 |
| ▸ | F10 | P00742 | 4/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814585 | 0.94 | SLC22A12 (0.48) | SLC22A12F2PRSS1F10PLG | |
| SCHEMBL4811451 | 0.87 | SLC22A12 (0.41) | SLC22A12F2PRSS1F10PRSS2 | |
| SCHEMBL4815014 | 0.84 | SLC22A12 (0.40) | SLC22A12F2PRSS1F10PLG | |
| SCHEMBL4814925 | 0.84 | PLA2G4A (0.40) | SLC22A12F2PRSS1F10PLG | |
| SCHEMBL4808748 | 0.82 | ALDH1A1 (0.43) | SLC22A12F2PRSS1F10PLG | |
| SCHEMBL4809607 | 0.82 | SLC22A12 (0.37) | SLC22A12F2PRSS1F10PLG | |
| SCHEMBL4812974 | 0.81 | TDP1 (0.40) | SLC22A12F2PRSS1F10 | |
| SCHEMBL4806730 | 0.81 | SLC22A12 (0.37) | SLC22A12F2PRSS1F10PLG | |
| SCHEMBL4813962 | 0.80 | KMT2A (0.38) | SLC22A12F2PRSS1F10PLG | |
| SCHEMBL4813787 | 0.80 | KDM4E (0.46) | SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417063-B2 | Bicyclic heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-26 | — | — | US | claimed |