Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17438091 | 0.89 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 | |
| SCHEMBL30232602 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 | |
| SCHEMBL297632 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 | |
| SCHEMBL932824 | 0.79 | ALDH1A1 (0.55) | SMN1; SMN2KDM4CPLA2G4AALDH1A1KMT2A | |
| SCHEMBL167425 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 | |
| SCHEMBL6314796 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 | |
| SCHEMBL31373302 | 0.76 | KDM4C (0.58) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 | |
| SCHEMBL31373301 | 0.76 | KDM4C (0.58) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 | |
| SCHEMBL29625285 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 | |
| SCHEMBL6877868 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4CPLA2G4AALDH1A1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |