Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23113939 | 0.79 | PDK2 (0.34) | KDM4EPKMKMT2AGRNSORT1 | |
| SCHEMBL6683087 | 0.79 | KDM4E (0.36) | KDM4EPKMGRNSORT1MAPK1 | |
| SCHEMBL5906720 | 0.78 | SSTR5 (0.35) | KDM4EPKMMEN1KMT2AGRN | |
| SCHEMBL19449357 | 0.74 | ALKBH1 (0.38) | KDM4EKMT2AGRNSORT1PDK2 | |
| SCHEMBL17646571 | 0.74 | KDM4E (0.39) | KDM4EPKMMEN1KMT2AMAPK1 | |
| SCHEMBL3209466 | 0.74 | L3MBTL1 (0.43) | ALDH1A1LMNATSHR | |
| SCHEMBL631704 | 0.74 | KDM4E (0.39) | KDM4EKMT2AMAPK1PTGER1LMNA | |
| SCHEMBL23401916 | 0.73 | — | — | |
| SCHEMBL19121426 | 0.71 | KDM4E (0.34) | KDM4EKMT2AGRNSORT1PDK2 | |
| SCHEMBL920103 | 0.69 | PDK2 (0.32) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |