Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2134930 | 0.84 | BLM (0.58) | PKMPOLBTDP1MEN1KMT2A | |
| SCHEMBL24022828 | 0.79 | NPC1 (0.61) | NPC1RAB9APKMKCNN4POLB | |
| SCHEMBL6312637 | 0.79 | NPC1 (0.48) | NPC1RAB9APKMPOLBTDP1 | |
| SCHEMBL10518218 | 0.79 | NPC1 (0.48) | NPC1RAB9APKMPOLBTDP1 | |
| Benzoic Acid SCHEMBL27848781 | 0.76 | TSHR (0.64) | NPC1RAB9APKMKCNN4POLB | |
| SCHEMBL17068941 | 0.75 | ALDH1A1 (0.70) | NPC1RAB9APOLBTDP1MEN1 | |
| SCHEMBL7907022 | 0.75 | MEN1 (0.54) | NPC1RAB9APKMPOLBTDP1 | |
| SCHEMBL9729472 | 0.75 | NPC1 (0.47) | NPC1RAB9APKMPOLBTDP1 | |
| SCHEMBL7940606 | 0.75 | ALDH1A1 (0.70) | NPC1RAB9APOLBTDP1MEN1 | |
| SCHEMBL251921 | 0.75 | ALDH1A1 (0.70) | NPC1RAB9APOLBTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7323563-B2 | Hydroxamic acid derivatives as antibacterials | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 2008-01-29 | — | — | US | disclosed |
| EP-1754477-A2 | Hydroxamic acid derivatives as antibacterials | Vernalis (Oxford) Limited (GB) | 2007-02-21 | — | — | EP | disclosed |
| EP-1079819-B1 | HYDROXAMIC ACID DERIVATIVES AS ANTIBACTERIALS | VERNALIS OXFORD LTD (GB) | 2006-12-06 | — | — | EP | disclosed |
| US-20060211732-A1 | Hydroxamic acid derivatives as antibacterials | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 2006-09-21 | — | — | US | disclosed |
| US-6992190-B2 | Hydroxamic acid derivatives as antibacterials | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 2006-01-31 | — | — | US | disclosed |
| US-20020198241-A1 | Hydroxamic acid derivatives as antibacterials | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 2002-12-26 | — | — | US | disclosed |
| US-6441042-B1 | HYDROXYAMIDES | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2002-08-27 | — | — | US | disclosed |
| EP-1079819-A1 | HYDROXAMIC ACID DERIVATIVES AS ANTIBACTERIALS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059568-A1 | HYDROXAMIC ACID DERIVATIVES AS ANTIBACTERIALS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211732-A1 | Hydroxamic acid derivatives as antibacterials | SLC7A1, EGLN2, PIGS | NPC1 2360/4885RAB9A 2949/4885PKM 3005/4885 |
| US-20020198241-A1 | Hydroxamic acid derivatives as antibacterials | SLC7A1, EGLN2, PIGS | NPC1 2124/4885RAB9A 3012/4885PKM 3062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.