Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11273 | 0.89 | TSHR (0.58) | TSHRCNR1HPGDSMN1; SMN2HTT | |
| SCHEMBL23299716 | 0.86 | TSHR (0.59) | TSHRHPGDSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL23478140 | 0.82 | TSHR (0.65) | TSHRCNR1HPGDSMN1; SMN2HTT | |
| SCHEMBL19726992 | 0.81 | L3MBTL1 (0.41) | TSHRCNR1L3MBTL1KMT2AMEN1 | |
| SCHEMBL17253450 | 0.80 | TSHR (0.51) | TSHRCNR1HPGDSMN1; SMN2HTT | |
| SCHEMBL19727004 | 0.80 | L3MBTL1 (0.40) | TSHRCNR1L3MBTL1KMT2AMEN1 | |
| SCHEMBL19727002 | 0.80 | TSHR (0.35) | TSHRALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL10124136 | 0.79 | MCL1 (0.48) | CNR1ALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL19821398 | 0.77 | CA2 (0.37) | TSHRSMN1; SMN2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL19727009 | 0.77 | CA2 (0.34) | TSHRSMN1; SMN2ALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740579-B1 | TRICYCLIC PYRAZOLE KINASE INHIBITORS | ABBVIE INC (US) | 2015-08-19 | — | — | EP | disclosed |
| US-7468371-B2 | Tricyclic pyrazole kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-20060014816-A1 | Tricyclic pyrazole kinase inhibitors | ABBVIE INC. | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014816-A1 | Tricyclic pyrazole kinase inhibitors | PRKDC, PRKACA, PIK3C3 | TSHR 3172/4885CNR1 2896/4885HPGD 2092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.