Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | GALK1 | P51570 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10748815 | 0.82 | MAPT (0.55) | SMN1; SMN2HTTALOX5MAPTLMNA | |
| SCHEMBL9805088 | 0.80 | HTT (0.73) | SMN1; SMN2HTTMAPTLMNANPC1 | |
| SCHEMBL2659216 | 0.77 | TSHR (0.49) | SMN1; SMN2HTTMAPTLMNANPC1 | |
| SCHEMBL6536223 | 0.77 | TSHR (0.62) | HTTALOX5MAPTLMNANPC1 | |
| Pyrrole SCHEMBL9864136 | 0.76 | HTT (0.66) | SMN1; SMN2HTTMAPTLMNANPC1 | |
| SCHEMBL31619940 | 0.75 | PRKCZ (0.56) | SMN1; SMN2HTTMAPTLMNANPC1 | |
| SCHEMBL4817673 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTALOX5PTGESMAPT | |
| SCHEMBL10455857 | 0.74 | CA12 (0.63) | SMN1; SMN2MAPTLMNAMEN1KMT2A | |
| SCHEMBL16851058 | 0.74 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTALOX5PTGESMAPT | |
| SCHEMBL688430 | 0.74 | PRKCZ (0.63) | MAPTLMNAMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |