Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 | Q05940 | 2/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818251 | 0.79 | SLC18A2 (0.64) | SLC18A2 | |
| SCHEMBL4817496 | 0.78 | HRH3 (0.49) | HRH3 | |
| SCHEMBL3781357 | 0.78 | SIGMAR1 (0.51) | SIGMAR1KCNH2 | |
| SCHEMBL3781355 | 0.78 | SIGMAR1 (0.51) | SIGMAR1KCNH2 | |
| SCHEMBL31406209 | 0.77 | HRH3 (0.59) | HRH3SIGMAR1KCNH2 | |
| SCHEMBL8705051 | 0.76 | CHRNB4 (0.60) | HRH3SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL8702919 | 0.76 | CHRNB4 (0.59) | HRH3SIGMAR1KCNH2 | |
| Lobelane SCHEMBL13845051 | 0.75 | SLC18A2 (1.00) | SLC18A2KCNH2 | |
| Lobelane SCHEMBL14178962 | 0.75 | SLC18A2 (1.00) | SLC18A2KCNH2 | |
| Lobelane SCHEMBL14178959 | 0.75 | SLC18A2 (1.00) | SLC18A2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368443-B2 | 2,6-disubstituted piperidines and piperazine compounds | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2008-05-06 | — | — | US | disclosed |
| US-20040266824-A1 | 2,6-disubstituted piperidines and piperazine compounds | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266824-A1 | 2,6-disubstituted piperidines and piperazine compounds | GRM5, GRM6, SLC1A2 | SLC18A2 11/4885HRH3 1708/4885SIGMAR1 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.