Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481777 | 0.78 | TSHR (0.37) | TSHRESR1MYCALOX15PTPN7 | |
| SCHEMBL9946130 | 0.75 | KMO (0.49) | TSHRMYCALOX15PTPN7HSD17B10 | |
| SCHEMBL488607 | 0.74 | TSHR (0.46) | TSHRALOX15MEN1KMT2ATDP1 | |
| SCHEMBL10148368 | 0.73 | CREBBP (0.50) | TSHRESR1MYCALOX15PTPN7 | |
| SCHEMBL11894061 | 0.72 | TDP1 (0.43) | TSHRESR1MYCALOX15PTPN7 | |
| SCHEMBL28754473 | 0.71 | RXRB (0.39) | ESR1MYCHSD17B10MEN1KMT2A | |
| SCHEMBL4946903 | 0.70 | KMO (0.54) | TSHRESR1MYCALOX15PTPN7 | |
| SCHEMBL4951622 | 0.69 | KMO (0.57) | TSHRESR1MYCALOX15PTPN7 | |
| SCHEMBL29421064 | 0.68 | CES2 (0.63) | TSHRESR1MYCALOX15PTPN7 | |
| SCHEMBL310259 | 0.68 | CES2 (0.63) | TSHRESR1MYCALOX15PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |