Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.65 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.58 |
| ▸ | MARK3 | P27448 | 3/20 | 0.58 |
| ▸ | FLT3 | P36888 | 3/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.57 |
| ▸ | MELK | Q14680 | 2/20 | 0.57 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | AKT2 | P31751 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810415 | 0.92 | CHEK1 (0.64) | CHEK1RPS6KB1MARK3FLT3RPS6KA3 | |
| SCHEMBL4813654 | 0.84 | KDR (0.68) | CHEK1RPS6KB1MARK3FLT3RPS6KA3 | |
| SCHEMBL4808871 | 0.84 | CHEK1 (0.59) | CHEK1RPS6KB1MARK3FLT3RPS6KA3 | |
| SCHEMBL6792772 | 0.83 | CHEK1 (0.70) | CHEK1RPS6KB1MARK3FLT3RPS6KA3 | |
| SCHEMBL4811728 | 0.83 | CHEK1 (0.58) | CHEK1RPS6KB1MARK3FLT3RPS6KA3 | |
| SCHEMBL4813399 | 0.83 | CHEK1 (0.71) | CHEK1 | |
| SCHEMBL4813383 | 0.83 | CHEK1 (0.71) | CHEK1 | |
| SCHEMBL4813279 | 0.82 | CHEK1 (0.65) | CHEK1RPS6KB1MARK3FLT3RPS6KA3 | |
| SCHEMBL4814631 | 0.81 | CHEK1 (0.58) | CHEK1RPS6KB1MARK3FLT3RPS6KA3 | |
| SCHEMBL4813598 | 0.81 | CHEK1 (0.63) | CHEK1RPS6KB1MARK3FLT3RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | claimed |
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | claimed |
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | CHEK1 73/4885RPS6KB1 133/4885MARK3 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.