Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.70 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | MARK3 | P27448 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.54 |
| ▸ | MELK | Q14680 | 2/20 | 0.54 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.54 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4813654 | 0.89 | KDR (0.68) | CHEK1KDRRETMARK3RPS6KA3 | |
| SCHEMBL4813383 | 0.84 | CHEK1 (0.71) | CHEK1 | |
| SCHEMBL4813399 | 0.84 | CHEK1 (0.71) | CHEK1 | |
| SCHEMBL4817862 | 0.83 | CHEK1 (0.65) | CHEK1RETMARK3RPS6KA3MELK | |
| SCHEMBL6787268 | 0.83 | CHEK1 (1.00) | CHEK1KDR | |
| SCHEMBL4810415 | 0.82 | CHEK1 (0.64) | CHEK1RETMARK3RPS6KA3MELK | |
| SCHEMBL4811728 | 0.81 | CHEK1 (0.58) | CHEK1KDRRETMARK3RPS6KA3 | |
| SCHEMBL4818180 | 0.80 | CHEK1 (1.00) | CHEK1KDR | |
| SCHEMBL4807960 | 0.80 | CHEK1 (1.00) | CHEK1KDR | |
| SCHEMBL4809009 | 0.80 | CHEK1 (0.80) | CHEK1KDRRETMARK3RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | CHEK1 73/4885KDR 1024/4885RET 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.