Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30089557 | 0.84 | PTGS1 (0.53) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL20221599 | 0.84 | ESR1 (0.55) | GSK3BPTPN1PTGS1PTGS2LMNA | |
| SCHEMBL2140146 | 0.82 | PTGS1 (0.52) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL9441164 | 0.82 | PTGS1 (0.52) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL6140804 | 0.81 | GSK3B (0.53) | GSK3BPTPN1 | |
| SCHEMBL13643238 | 0.81 | GSK3B (0.53) | GSK3BPTPN1 | |
| SCHEMBL13643171 | 0.81 | GSK3B (0.49) | GSK3BPTPN1 | |
| SCHEMBL9543302 | 0.81 | FAAH (0.59) | GSK3BPTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL21064585 | 0.79 | PTGS1 (0.57) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL14297902 | 0.79 | BLM (0.55) | PTGS1PTGS2LMNACYP2C9AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307863-B | Pyrimidine derivatives, horticultural insecticides comprising said derivatives and method of use thereof | NIHON NOHYAKU CO LTD | 2014-05-07 | — | — | CN | disclosed |
| CN-102307863-A | Pyrimidine derivatives, horticultural insecticides comprising said derivatives and method of use thereof | NIHON NOHYAKU CO LTD | 2012-01-04 | — | — | CN | disclosed |
| US-7402602-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) | 2008-07-22 | — | — | US | disclosed |
| US-20070099975-A1 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) | 2007-05-03 | — | — | US | disclosed |
| US-7157483-B2 | Imidazole derivatives modulating the sodium channels | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2007-01-02 | — | — | US | disclosed |
| US-20060069146-A1 | Imidazole derivatives modulating the sodium channels | SCRAS | 2006-03-30 | — | — | US | disclosed |
| EP-1401432-B1 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOD CONSEILS RECH APPLIC (FR) | 2005-09-14 | — | — | EP | disclosed |
| US-20040198792-A1 | Imidazole derivatives modulating the sodium channels | IPSEN PHARMA S.A.S. (FR) | 2004-10-07 | — | — | US | disclosed |
| EP-1401432-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002102375-A2 | IMIDAZOLE DERIVATIVES FOR MODULATING SODIUM CHANNELS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.) (FR) | 2002-12-27 | — | — | WO | disclosed |
| US-4675419-A | Process for preparing α-hydroxy-acids and compounds obtained by this process | SANOFI (FR) | 1987-06-23 | — | — | US | disclosed |
| US-4033978-A | Thiacycl[2.2.2]azine carboxylic acids | SYNTEX (U.S.A.) INC. (US) | 1977-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198792-A1 | Imidazole derivatives modulating the sodium channels | SCN1A, SCN1B, TRPV1 | GSK3B 986/4885PTPN1 1968/4885PTGS1 573/4885 |
| US-20070099975-A1 | Imidazole derivatives modulating the sodium channels | SCN2B, KCNJ2, SCN1B | GSK3B 2860/4885PTPN1 2100/4885PTGS1 1129/4885 |
| US-20060069146-A1 | Imidazole derivatives modulating the sodium channels | SCN1B, SCN1A, SCN2B | GSK3B 677/4885PTPN1 2999/4885PTGS1 629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.