Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.41 |
| ▸ | NOS3 | P29474 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424624 | 0.81 | NOS1 (0.57) | NOS1NOS3EGFRNOS2MEN1 | |
| Ammonia Solution, Strong SCHEMBL253374 | 0.80 | NOS1 (0.44) | NOS1NOS3EGFRNOS2MEN1 | |
| SCHEMBL253373 | 0.80 | NOS1 (0.42) | NOS1NOS3EGFRNOS2MEN1 | |
| SCHEMBL4286592 | 0.72 | PTGER1 (0.41) | PTGER1 | |
| SCHEMBL7077507 | 0.70 | NOS3 (0.43) | NOS1NOS3PTGER1 | |
| SCHEMBL4286467 | 0.65 | NOS1 (0.89) | NOS1NOS3NOS2 | |
| SCHEMBL5778138 | 0.65 | NOS1 (0.47) | NOS1NOS3PTGER1 | |
| SCHEMBL7073841 | 0.64 | KDM4E (0.37) | NOS1NOS3PTGER1 | |
| SCHEMBL7073102 | 0.60 | NOS1 (1.00) | NOS1NOS3NOS2 | |
| SCHEMBL6581790 | 0.60 | MAOB (0.44) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910385-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019346-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |