Sugi Predict

Sugi Predict / Compounds / SCHEMBL482061

SCHEMBL482061

SCHEMBL482061

O=C1CCC(c2ccc(Br)cc2)N1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4A P27815 1/20 0.44
▸ PDE4B Q07343 1/20 0.44
▸ PDE4C Q08493 1/20 0.44
▸ PDE4D Q08499 1/20 0.44
▸ ALDH1A1 P00352 3/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ HDAC2 Q92769 1/20 0.41
▸ CRBN Q96SW2 2/20 0.41
▸ DDB1 Q16531 1/20 0.40
▸ CYP3A4 P08684 3/20 0.39
▸ CYP2C9 P11712 3/20 0.39
▸ CYP2C19 P33261 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ TSHR P16473 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ ESR1 P03372 1/20 0.37
▸ ESR2 Q92731 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4142288 1.00 PDE4A (0.44) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL22201147 1.00 PDE4A (0.44) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL14458021 0.95 SMN1; SMN2 (0.43) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL2199831 0.89 SMN1; SMN2 (0.41) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL23878342 0.81 TDP1 (0.46) PDE4APDE4BPDE4CPDE4DHDAC2
SCHEMBL22039449 0.81 TDP1 (0.46) PDE4APDE4BPDE4CPDE4DHDAC2
SCHEMBL22190402 0.81 PDE4A (0.44) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL22201140 0.81 PDE4A (0.44) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL14458009 0.81 ALDH1A1 (0.54) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL22201146 0.81 ALDH1A1 (0.54) PDE4APDE4BPDE4CPDE4DALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12528822-B2 Cycloalkane-1,3-diamine derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2026-01-20 — — US disclosed
EP-4619406-A1 TRICYCLIC COMPOUNDS Schrödinger, Inc. (US) 2025-09-24 — — EP disclosed
US-20250230168-A1 AZASPIRO WRN INHIBITORS GILEAD SCIENCES, INC. 2025-07-17 — — US disclosed
WO-2025137640-A1 AZASPIRO WRN INHIBITORS GILEAD SCIENCES, INC. (US) 2025-06-26 — — WO disclosed
EP-4545515-A1 BCL-2 INHIBITORS BeiGene Switzerland GmbH (CH) 2025-04-30 — — EP disclosed
US-20240376104-A1 Bcl-2 Inhibitors BEIGENE LTD. (KY) 2024-11-14 — — US disclosed
US-12077536-B2 BCL-2 inhibitors BEIGENE, LTD. (KY) 2024-09-03 — — US disclosed
US-12060365-B2 Cycloalkane-1,3-diamine derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-08-13 — — US disclosed
US-11998901-B2 Metal complex, method for producing same, and method for producing gamma-lactam compound using same INSTITUTE FOR BASIC SCIENCE (KR) 2024-06-04 — — US disclosed
WO-2024107393-A1 TRICYCLIC COMPOUNDS SCHRÖDINGER, INC. (US) 2024-05-23 — — WO disclosed
US-6399771-B1 AGRICULTURE; VETERINARY MEDICINE BAYER AKTIENGESELLSCHAFT (DE) 2002-06-04 — — US disclosed
CN-1323304-A 2-hetaryl-3,4-dihydro-2h-pyrrole derivatives BAYER AG (DE) 2001-11-21 — — CN disclosed
CN-1309636-A 2-(2-chlorophenyl)-3,4-dihydro-2H-pyrrol derivs. BAYER AG (DE) 2001-08-22 — — CN disclosed
US-6274613-B1 APPLYING COMPOUNDS SUCH AS A GAMMA-ETHOXY-GAMMA-BUTYROLACTAM TO PESTS AND/OR THEIR HABITATS BAYER AKTIENGESELLSCHAFT (DE) 2001-08-14 — — US disclosed
EP-1121357-A1 2-HETARYL-3,4-DIHYDRO-2H-PYRROLE DERIVATIVES Bayer Aktiengesellschaft (DE) 2001-08-08 — — EP disclosed
EP-1080072-A1 2-(2-CHLOROPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES Bayer Aktiengesellschaft (DE) 2001-03-07 — — EP disclosed
EP-1077938-A1 2-(2-METHYLPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES BAYER AG (DE) 2001-02-28 — — EP disclosed
WO-2000021958-A1 2-HETARYL-3,4-DIHYDRO-2H-PYRROLE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2000-04-20 — — WO disclosed
WO-1999059967-A1 2-(2-METHYLPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1999-11-25 — — WO disclosed
WO-1999059968-A1 2-(2-CHLOROPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1999-11-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250230168-A1 AZASPIRO WRN INHIBITORS WRN, RECQL, BLM PDE4A 1033/4885PDE4B 1605/4885PDE4C 1726/4885
US-12077536-B2 BCL-2 inhibitors BCL2, BCL2L1, BCL2L2 PDE4A 3327/4885PDE4B 2805/4885PDE4C 3515/4885
US-12060365-B2 Cycloalkane-1,3-diamine derivative MLLT1, MEN1, MLLT3 PDE4A 3538/4885PDE4B 3597/4885PDE4C 4036/4885
US-11998901-B2 Metal complex, method for producing same, and method for producing gamma-lactam compound using same COASY, NOTUM, MRPL21 PDE4A 4069/4885PDE4B 4031/4885PDE4C 3520/4885
US-20240376104-A1 Bcl-2 Inhibitors BCL2, BCL2L1, BCL2L2 PDE4A 3327/4885PDE4B 2805/4885PDE4C 3515/4885
US-12528822-B2 Cycloalkane-1,3-diamine derivative MLLT1, MLLT3, PRMT6 PDE4A 4426/4885PDE4B 4449/4885PDE4C 4502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.