Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820716 | 0.76 | HTR2A (0.50) | HTR2AHRH1DRD2RET | |
| SCHEMBL5548408 | 0.74 | CNR2 (0.38) | — | |
| SCHEMBL1574700 | 0.73 | PRKCD (0.41) | HTR2AHRH1PRKCD | |
| SCHEMBL27296044 | 0.71 | HTR2A (0.47) | HTR2AHRH1HTR2CDRD2RET | |
| SCHEMBL6305591 | 0.70 | CES2 (0.40) | HTR2A | |
| SCHEMBL877438 | 0.68 | HTR2A (0.56) | HTR2A | |
| SCHEMBL5508649 | 0.68 | HTR2A (0.43) | HTR2AHRH1HTR2CDRD2SLC6A2 | |
| SCHEMBL1325541 | 0.67 | RAB9A (0.44) | — | |
| SCHEMBL6061696 | 0.67 | HTR2A (0.54) | HTR2A | |
| SCHEMBL6060938 | 0.67 | HTR2A (0.54) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931636-A1 | ISOQUINOLINES AS IGF-1R INHIBITORS | Analytecon S.A. (CH) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007029106-A1 | ISOQUINOLINES AS IGF-1R INHIBITORS | ANALYTECON SA (CH) | 2007-03-15 | — | — | WO | disclosed |