Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | LDHB | P07195 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | AOC1 | P19801 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2211618 | 0.88 | LDHA (0.51) | APPLDHALDHBPDE10AADORA2A | |
| SCHEMBL481747 | 0.74 | CCNT1 (0.47) | APPLDHALDHBPDE10AADORA2A | |
| SCHEMBL481746 | 0.74 | CCNT1 (0.47) | APPLDHALDHBPDE10AADORA2A | |
| SCHEMBL1192967 | 0.74 | CCNT1 (0.49) | LDHALDHBPDE10AADORA2AHIF1A | |
| SCHEMBL13649042 | 0.72 | KMT2A (0.44) | APPADORA2AGRM4IDO1TDO2 | |
| SCHEMBL14905695 | 0.72 | TDO2 (0.53) | APPLDHALDHBIDO1TDO2 | |
| SCHEMBL14172930 | 0.72 | APP (0.43) | APPLDHALDHBGRM4IDO1 | |
| SCHEMBL4407126 | 0.71 | PDE10A (0.39) | LDHALDHBPDE10AADORA2AJAK1 | |
| SCHEMBL4407124 | 0.71 | PDE10A (0.39) | LDHALDHBPDE10AADORA2AJAK1 | |
| SCHEMBL4071077 | 0.70 | KMT2A (0.42) | APPLDHALDHBADORA2AGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |