Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4821213 | 1.00 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8269866 | 0.90 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL4825963 | 0.87 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4819624 | 0.87 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4819618 | 0.87 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4818681 | 0.83 | ALDH1A1 (0.59) | ALDH1A1CYP3A4TSHRTDP1KMT2A | |
| SCHEMBL4824357 | 0.81 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL4824365 | 0.81 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL4816976 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4816968 | 0.79 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470723-B2 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107339-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | PDE4A 2547/4885PDE4B 2484/4885PDE4C 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.