Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.56 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4824715 | 1.00 | CHRNB2 (0.56) | CHRNB2CHRNA4SUV39H2HRH4PIK3CG | |
| SCHEMBL4827854 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4SUV39H2HRH4CHRNB4 | |
| SCHEMBL4827293 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4SUV39H2HRH4CHRNB4 | |
| SCHEMBL4826171 | 0.84 | CHRNB2 (0.54) | CHRNB2CHRNA4HRH4CHRNB4CHRNA3 | |
| SCHEMBL4825377 | 0.84 | CHRNB2 (0.54) | CHRNB2CHRNA4HRH4CHRNB4CHRNA3 | |
| SCHEMBL4821233 | 0.82 | CHRNB2 (0.52) | CHRNB2CHRNA4HRH4DOT1L | |
| SCHEMBL4823942 | 0.82 | CHRNB2 (0.52) | CHRNB2CHRNA4HRH4DOT1L | |
| SCHEMBL4828980 | 0.82 | CHRNB2 (0.58) | CHRNB2CHRNA4SUV39H2PIK3CGCHRNB4 | |
| SCHEMBL4828801 | 0.82 | CHRNB2 (0.58) | CHRNB2CHRNA4SUV39H2PIK3CGCHRNB4 | |
| SCHEMBL4827654 | 0.82 | HRH4 (0.47) | HRH4DOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | claimed |
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | disclosed |