Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828801 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNA4ADRA1DADRA1BADRA1A | |
| SCHEMBL4827876 | 0.83 | CHRNB2 (0.56) | CHRNB2CHRNA4SUV39H2CHRNB4CHRNA3 | |
| SCHEMBL4822042 | 0.83 | CHRNB2 (0.56) | CHRNB2CHRNA4SUV39H2CHRNB4CHRNA3 | |
| SCHEMBL4824715 | 0.82 | CHRNB2 (0.56) | CHRNB2CHRNA4SUV39H2CHRNB4CHRNA3 | |
| SCHEMBL4822146 | 0.82 | CHRNB2 (0.56) | CHRNB2CHRNA4SUV39H2CHRNB4CHRNA3 | |
| SCHEMBL4827535 | 0.82 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3PIM1 | |
| SCHEMBL4829280 | 0.82 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3PIM1 | |
| SCHEMBL7149209 | 0.82 | CHRNB2 (0.76) | CHRNB2CHRNA4SUV39H2PIK3CG | |
| SCHEMBL4822010 | 0.80 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3PIM1 | |
| SCHEMBL4827877 | 0.80 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | claimed |
| US-7332504-B2 | Heterocyclic substituted aminoazacycles useful as central nervous system agents | ABBOTT LABORATORIES (US) | 2008-02-19 | — | — | US | disclosed |