Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215320 | 0.79 | BRD4 (0.75) | BRD4ALDH1A1MAPTCDC7TAS2R38 | |
| SCHEMBL1156069 | 0.78 | BRD4 (0.63) | BRD4ALDH1A1HPGDMAPTTSHR | |
| SCHEMBL7173993 | 0.76 | BRD4 (1.00) | BRD4ALDH1A1MAPTCDC7 | |
| SCHEMBL1450398 | 0.76 | BRD4 (0.71) | BRD4ALDH1A1MAPTCDC7TAS2R38 | |
| SCHEMBL14134219 | 0.72 | HDAC7 (0.57) | ALDH1A1HPGDMAPTTSHRMAPK1 | |
| SCHEMBL15444821 | 0.72 | BRD4 (0.63) | BRD4ALDH1A1HPGDMAPTCDC7 | |
| SCHEMBL14134248 | 0.72 | HPGD (0.51) | ALDH1A1HPGDMAPTTSHRMAPK1 | |
| SCHEMBL375495 | 0.71 | BRD4 (0.58) | BRD4ALDH1A1MAPTTSHRMAPK1 | |
| SCHEMBL3629780 | 0.71 | MEN1 (0.66) | ALDH1A1HPGDMAPTTSHRMAPK1 | |
| SCHEMBL29822323 | 0.71 | TP53 (0.69) | ALDH1A1HPGDMAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101346381-A | New anti-malaria derivatives of 4-aminoquinoline | NEED PHARMACEUTICALS S R L (IT) | 2009-01-14 | — | — | CN | disclosed |
| EP-1937686-A1 | NEW ANTI-MALARIA DERIVATIVES OF 4-AMINOQUINOLINE | Need Pharmaceuticals S.r.l. (IT) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007045987-A1 | NEW ANTI-MALARIA DERIVATIVES OF 4-AMINOQUINOLINE | NEED PHARMACEUTICALS S.R.L. (IT) | 2007-04-26 | — | — | WO | disclosed |