Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | GCGR | P47871 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1156069 | 0.87 | BRD4 (0.63) | BRD4GCGRALDH1A1RAB9ANPC1 | |
| SCHEMBL2215320 | 0.77 | BRD4 (0.75) | BRD4ALDH1A1MAPT | |
| SCHEMBL4105383 | 0.76 | ALDH1A1 (0.52) | ALDH1A1RAB9ATDP1NPC1MAPK1 | |
| SCHEMBL2588443 | 0.75 | ALDH1A1 (0.72) | ALDH1A1RAB9ATDP1NPC1MAPK1 | |
| SCHEMBL19727271 | 0.74 | TUBB4A (0.53) | BRD4GCGRALDH1A1RAB9ATDP1 | |
| SCHEMBL7173993 | 0.74 | BRD4 (1.00) | BRD4ALDH1A1MAPT | |
| SCHEMBL1450398 | 0.74 | BRD4 (0.71) | BRD4ALDH1A1MAPT | |
| SCHEMBL1156279 | 0.73 | KMT2A (0.67) | GCGRALDH1A1RAB9ANPC1MAPK1 | |
| SCHEMBL7997890 | 0.73 | ALDH1A1 (0.56) | BRD4GCGRALDH1A1RAB9ATDP1 | |
| SCHEMBL13399325 | 0.73 | TUBB4A (0.52) | BRD4GCGRALDH1A1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222274-B2 | Pyrrole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-07-17 | — | — | US | disclosed |
| EP-1988075-B1 | PYRROLE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-20090036421-A1 | Pyrrole Derivative or Salt Thereof | ASTELLAS PHARMA INC (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1988075-A1 | PYRROLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2008-11-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036421-A1 | Pyrrole Derivative or Salt Thereof | HTR7, HTR2B, SSTR5 | BRD4 874/4885GCGR 207/4885ALDH1A1 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.